Following an initial teaser, Netflix returns with the first official trailer for its new limited series, Maniac. Maniac stars Jonah Hill and Emma Stone as Owen Milgrim and Annie Landsberg, two strangers who are subjects of a mysterious pharmaceutical experiment, which — as to be expected — goes inexplicably awry.

Justin Theroux also features in the series, portraying Dr. James K. Mantleray, leader of the clinical drug trial and inventor of a pill that is said to repair the mind. Unfortunately, however, upon administering the medicine, “things do not go as planned,” according to Netflix.

Cary Fukunaga (True Detective, Beasts of No Nation) directs the 10-part program, arriving on Netflix September 21.

In related news, here's how Netflix decides to renew or cancel shows.

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